What is NAD+?

NAD+, or nicotinamide adenine dinucleotide, is an essential resource to maintain the normal operation of cells. It is a coenzyme that can be found in every cell in your body. It is responsible for 95% of the creation of energy in the body and involved in hundreds of metabolic processes. NAD+ could significantly increase the sirtuin activities which control our basic metabolism and repair damaged DNA.

NAD+ is a naturally occurring compound that determines how quickly our cells age. It plays a critical role in restoring the body to its top performing original state and improvement of longevity.

NAD+ Levels Decline with Age

During the age of 40-60, NAD + levels in our body decline up to 50%. Low NAD+ level means our body cannot function well in turning nutrients into energy in metabolism or regulating other cellular functions which leads to age related pathology and various diseases.

What are NMN & NR?

NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside), are two well-known precursors to NAD+. They become NAD+ through a series of chemical transformations. NR chemically transforms to NMN and then ultimately becomes NAD+ in our body.

Studies in mouse models have shown that supplementation with NMN can increase lifespan and decrease age-related frailty. This is likely due to NAD+ which can activate cellular repair pathways and which can improve a wide variety of physiological changes including restoring muscle function and athletic performance, improving brain regeneration and restoring energy levels etc.

NR vs NMN vs NAD+

NMN

NAD+

Dosage

Oral intake needs a much higher dose (a 180-pound man is like over 2000 mg per day)

✔️

Oral dosage is much lower (around 200-400 mg per day)

The molecule size is big. It is difficult to be taken up by cell.

Effects

There was trending improvement in the vascular system, but there was no effect on endurance.

✔️

It can help mitochondrial disease and increase endurance.

High doses of NAD+ may inhibit the sirtuins, and PARP and interfere with DNA repair.

From The Research to Your Home

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